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doi: 10.1124/mol.104.007138 65 AnsariMSautyGLabudaMGagnVRousseauJMoghrabiAet al

Although current literature provides limited detail on pathways such as A20, SIRT1, and Nrf2, available evidence suggests that any endogenous mechanism capable of suppressing NLRP3 activation, reducing NETosis, or mitigating fibrosis has the potential to delay the transition from acute gouty inflammation to chronic tophaceous lesions (181183)

Nanocarriers, including liposomes, polymeric nanoparticles, and solid lipid nanoparticles (SLNs), protect antioxidants from degradation in the gastrointestinal tract and systemic circulation

PMID 17175815

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The metabolism process takes place in the intestines, liver and kidneys and the accumulation tends to happen in those organs